胎盘生长因子预测子痫前期的研究进展
Research progress of placental growth factor in predicting preeclampsia
周梦兰 1欧明林1
作者信息
- 1. 桂林医学院第二附属医院中心实验室/广西糖脂代谢病重点实验室,广西 桂林 541000
- 折叠
摘要
子痫前期多发生在妊娠20周之后,严重影响母胎健康,是全球孕产妇和围生儿病死率升高的主要原因.因此,探索能加快诊断子痫前期的生物标志物尤为重要.建立孕早中期子痫前期的诊断模型是减少孕产妇和婴儿病死率的重中之重.该文结合国内外近年来的研究成果对子痫前期发病机制及胎盘生长因子等血管生成标志物的临床应用方面进行了综述,旨在提高子痫前期早期诊断率,降低孕产妇并发症风险和围生儿病死率.
Abstract
Pre-eclampsia,which mostly occurs often after 20 weeks of gestation,severely affects mater-nal and fetal health and is a major cause of increased maternal and perinatal mortality worldwide.Therefore,it is important to explore biomarkers that can expedite the diagnosis of preeclampsia.Establishing a diagnostic model for preeclampsia in early and mid-pregnancy is a top priority for reducing maternal and infant mortali-ty.In this article,we review the pathogenesis of pre-eclampsia and the clinical application of angiogenic mark-ers such as placental growth factor,with the aim of improving the early diagnosis of pre-eclampsia and reduc-ing the risk of maternal complications and perinatal morbidity and mortality.
关键词
胎盘生长因子/子痫前期/血管生成标志物/综述Key words
Placental growth factor/Preeclampsia/Angiogenesis markers/Review引用本文复制引用
基金项目
广西壮族自治区医疗卫生适宜技术开发与推广应用项目(S2022147)
出版年
2024
国家科技期刊平台
NSTL
万方数据