Predictive value of new inflammatory index in all-cause mortality in patients with diabetic kidney disease
Objective To explore the predictive effect of a new inflammatory index based on multiple peripheral blood indicators on all-cause mortality in patients with diabetic kidney disease(DKD).Methods The clinical data of DKD population in 10 cycles from 1999 to 2018 in the National Health and Nu-trition Examination Survey(NHANES)database were analyzed.Univariate and multivariate Cox regression analysis were uesd to explore the correlation between four new inflammatory indexes,including systemic im-mune inflammatory index(SII),neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR)and all-cause mortality in DKD patients.The accuracy of each index in predicting all-cause mortality in DKD patients was evaluated by the area under time-dependent receiver operat-ing characteristic curve(AUC).Results A total of 2 043 participants were included,with a median age of 70 years.SII,NLR,PLR and MLR were significantly associated with all-cause mortality in DKD patients(RR at Q4=1.61,1.61,1.28,1.62,95%CI 1.35-1.95,1.32-1.97,1.07-1.53,1.32-2.00,P<0.001,P<0.001,P=0.007,P<0.001).The AUC of SII,NLR,MLR and PLR were 67.68%,59.10%,58.31%and 61.89%,respectively.Conclusion Four new inflammatory indices are significantly associated with all-cause mortality in DKD patients.The new inflammatory index has predictive value for the follow-up of DKD patients.
国家科技期刊平台
NSTL
万方数据
