Analysis of clinicopathologic features and diagnosis of metaplastic breast cancer
Objective To investigate the clinicopathologic features and diagnostic of metaplastic breast cancer(MpBC).Methods A retrospective analysis of the clinical data of 46 patients with pathologically con-firmed MpBC admitted to the hospital from January 2014 to December 2022 was performed to analyze their clinicopathological features,outcomes and survival.The median follow-up time was 50.9 months.Results A total of 46 patients with median age of 52 years were female.The molecular subtype was triple-negative in 80.4%(37/46)of the patients,with spindle cell carcinoma being the most common histological subtype[32.6%(15/46)].All 46 patients underwent surgical treatment,and the most common distant metastasis was to the lungs[57.1%(8/14)].The 3-year and 5-year progression-free survival rates were 78.0%and 61.3%,respectively.The 3-year and 5-year overall survival rates were 82.9%and 64.3%,respectively.Tumor patho-logical grade 3,lymph node metastasis,and Ki-67>50%were the risk factors for the prognosis of MpBC pa-tients(P<0.05).Ki-67>50%was an independent risk factor for the prognosis of MpBC patients(P<0.05).Conclusion MpBC progresses rapidly,and poor overall survival,surgical excision is the treatment exci-sion for MpBC,and Ki-67>50%is an independent risk factor for its prognostic.
Metaplastic breast cancerClinicopathological featuresDiagnosisTherapyPrognosis
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