施万细胞促进头颈癌增殖、侵袭机制的研究进展
Research progress on the mechanism of Schwann cells promoting the proliferation and invasion of head and neck cancer
蔡永鹏 1苟黎明 2李勇2
作者信息
- 1. 重庆医科大学附属永川医院口腔科,重庆 402160
- 2. 重庆医科大学附属口腔医院颌面外二科,重庆 401147
- 折叠
摘要
头颈癌存在着广泛的神经周围浸润和肿瘤神经支配,在促进肿瘤进展的同时带来更差的预后.施万细胞(SCs)是一种神经胶质细胞,广泛分布于外周神经系统,参与了神经损伤修复.近年来,越来越多的研究表明,SCs在肿瘤微环境(TME)中扮演着重要角色.重编程SCs通过与肿瘤和神经进行信号交互,一方面,促进神经周围浸润和肿瘤神经支配;另一方面,直接作用于TME成分并促进肿瘤进展.该文主要讨论了SCs与癌症-神经的信号串扰模式,以及SCs相关信号在TME中的作用机制,并探讨了SCs相关头颈癌治疗干预的潜在靶点.
Abstract
There is extensive peripheral nerve infiltration and tumor innervation in head and neck canc-er,which promotes tumor progress and brings worse prognosis.Schwann cells(SCs)are a type of glial cells that are widely distributed in the peripheral nervous system and are involved in nerve injury repair.In recent years,more and more studies have shown that SCs play an important role in the tumor microenvironment(TME).Reprogrammed SCs promote peripheral nerve infiltration and tumor innervation through signal inter-action with tumor and nerves on the one hand,and directly act on TME components and promote tumor pro-gression on the other hand.This paper mainly discusses the cross-talk patterns of SCs and cancer-nerve sig-nals,as well as the mechanism of action of SCS-related signals in TME,and explore potential targets for thera-peutic intervention in SCS-related head and neck cancer.
关键词
施万细胞/头颈癌/增殖/侵袭/综述Key words
Schwann cell/Head and neck cancer/Proliferation/Invasion/Review引用本文复制引用
基金项目
重庆市卫生健康委员会2017年医学科研计划项目(2017ZDXM019)
出版年
2024
国家科技期刊平台
NSTL
万方数据