Research progress on the mechanism of Schwann cells promoting the proliferation and invasion of head and neck cancer
There is extensive peripheral nerve infiltration and tumor innervation in head and neck canc-er,which promotes tumor progress and brings worse prognosis.Schwann cells(SCs)are a type of glial cells that are widely distributed in the peripheral nervous system and are involved in nerve injury repair.In recent years,more and more studies have shown that SCs play an important role in the tumor microenvironment(TME).Reprogrammed SCs promote peripheral nerve infiltration and tumor innervation through signal inter-action with tumor and nerves on the one hand,and directly act on TME components and promote tumor pro-gression on the other hand.This paper mainly discusses the cross-talk patterns of SCs and cancer-nerve sig-nals,as well as the mechanism of action of SCS-related signals in TME,and explore potential targets for thera-peutic intervention in SCS-related head and neck cancer.
Schwann cellHead and neck cancerProliferationInvasionReview
国家科技期刊平台
NSTL
万方数据
