血管紧张素Ⅱ及其受体与循环系统疾病之间关系的研究进展
Research progress on the relationship between Angiotensin Ⅱ and its receptor and circulatory diseases
胡昱堃 1张欣 1侯颖1
作者信息
- 1. 西安医学院基础与转化医学研究所,陕西 西安 710021
- 折叠
摘要
血管紧张素Ⅱ(Ang Ⅱ)为肾素-血管紧张素系统中的主要活性肽,其与循环系统疾病,如心脏病、高血压、高血脂、脑卒中等疾病的发生与发展关系十分密切.Ang Ⅱ不仅参与了调节血压稳定和维持机体水盐平衡,而且是促进血管炎症反应,引起氧化应激损伤、血管内皮功能障碍引发循环系统疾病的影响因素.Ang Ⅱ在循环系统疾病的发生与发展过程中的作用一直是学术界研究的热点,因此,明确Ang Ⅱ与循环系统疾病之间的联系可为临床治疗循环系统疾病提供新的思路.
Abstract
Angiotensin Ⅱ(Ang Ⅱ)is the main active peptide in renin angiotensin system(RAS),which is closely related to the occurrence and development of circulatory diseases such as heart disease,hyper-tension,hyperlipidemia and stroke.Ang Ⅱ not only participates in the beneficial effects of regulating blood pressure stability and maintaining water and salt balance,but also promotes vascular inflammatory response,causes oxidative stress injury,vascular endothelial dysfunction and circulatory system diseases.The role of Ang Ⅱ in the occurrence and development of circulatory system diseases has always been the focus of academ-ic research.Therefore,clarifying the relationship between Ang Ⅱ and circulatory system diseases can provide new ideas for clinical treatment of circulatory system diseases.
关键词
血管紧张素Ⅱ/血管紧张素Ⅱ受体/循环系统疾病/综述Key words
Angiotensin Ⅱ/Angiotensin Ⅱ receptor/Disease of the circulatory system/Review引用本文复制引用
基金项目
陕西省科技厅一般(青年)项目(2022JQ-864)
陕西省教育厅专项科研计划项目(22JK0540)
大学生创新创业训练计划项目(S202111840027)
出版年
2024
国家科技期刊平台
NSTL
万方数据