HPV infection and genotype distribution among 8 919 women in the eastern region of Dongguan city
Objective To analyze the current characteristics of human papillomavirus(HPV)infection among women in the eastern region of Dongguan City,providing a theoretical basis for intervention measures against HPV infection,early screening for cervical cancer(CC),and the formulation of HPV vaccination pro-grams in this region.Methods A total of 8 919 women who underwent HPV genotyping tests at this hospital from September 2021 to June 2023 were selected.They were divided into five age groups:≤30 years group(2 159 cases),＞30-40 years group(3 501 cases),＞40-50 years group(2 291 cases),＞50-60 years group(787 cases),and＞60 years group(181 cases).The study period was evenly divided into two time periods:Group A from September 2021 to July 2022(4 565 cases)and Group B from August 2022 to June 2023(4 354 cases).The HPV infection status across different ages and time periods was statistically analyzed.Results The overall detection rate of HPV infection was 30.14％,with a single-type infection rate of 69.38％and a multiple-type infection rate of 30.62％.The more common high-risk HPV(HR-HPV)types were HPV52,58,16,53,and 51 type,while the more common low-risk HPV(LR-HPV)types were HPV81 and 6 type.The age distribution of HPV infection showed a"U"-shaped bimodal curve,with peaks at ≤30 years and＞60 years,with the highest infection rate in the＞60 years group.There were statistically significant differences in infection rates among different age groups(P＜0.05).The characteristics of HPV infection var-ied across time periods.In group A,the more common HR-HPV types were HPV52,16,53,68,and 58 type,while the common LR-HPV types were HPV81 and 42 type.In group B,the more common HR-HPV types were HPV52,58,16,56,and 51 type,and the common LR-HPV types were HPV81 and 11 type.Conclusion The HPV infection genotypes in the eastern region of Dongguan City are diverse,and the current situation is not optimistic,with a predominance of single HR-HPV types infections,particularly HPV52,58,16,53,and 51 type.CC prevention and control strategies should be tailored to different age and regional characteristics.
Human papillomavirusEpidemiological characteristicsGenotype distributionCer-vical cancerPrevention and controlVaccine
万方数据
