Objective To explore the predictive value of carbohydrate antigen 125(CA125)combined with platelet-to-lymphocyte ratio(PLR)in the diagnosis of early gastric cancer.Methods A total of 150 sus-pected gastric cancer patients admitted to this hospital from January 2020 to January 2023 were selected as the study subjects.Peripheral venous blood samples were collected to detect the levels of CA125,PLR,and their combined levels.Among them,87 cases were confirmed as benign lesions by gastroscopy or surgical pathologi-cal biopsy(54 cases of chronic non-atrophic gastritis and 33 cases of chronic atrophic gastritis),and 63 cases were diagnosed as early gastric cancer(including severe dysplasia).The levels of CA125 and PLR were com-pared between the two groups,and the influencing factors of early gastric cancer were analyzed.Receiver oper-ating characteristic(ROC)curves were plotted to analyze the value of the above indicators alone and in combi-nation in the diagnosis of early gastric cancer.Results Significant differences were observed in CA125,PLR,tumor location,smoking status,histological type,and depth of invasion between the two groups(P＜0.05).Multivariate logistic regression analysis revealed that tumor location,smoking status,CA125,and PLR were independent influencing factors for early gastric cancer(P＜0.05).The ROC curves showed that CA125 and PLR had similar diagnostic efficacy for early gastric cancer,but the combination of the two could effectively improve the diagnostic performance of each individual marker.The area under the curve(AUC)of the com-bined predictor for early gastric cancer was 0.856,with a 95％confidence interval of 0.837-0.951,a sensitivi-ty of 81.60％,and a specificity of 88.70％.Conclusion Tumor location,smoking status,CA125,and PLR are independent risk factors for early gastric cancer.CA125 and PLR may be helpful in identifying patients with early gastric cancer,and they are more easily accessible and cost-effective,making them more acceptable to patients.
关键词
糖类抗原/血小板与淋巴细胞比率/联合检测/早期胃癌/预测价值
Key words
Carbohydrate antigen 125/Platelet-to-lymphocyte ratio/Combined detection/Early gastric cancer/Predictive value
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