Alzheimer's disease(AD)is the most common neurodegenerative disorder,and effective treatments are still lacking.Identifying molecular biomarkers has become crucial for AD diagnosis and preven-tion.This article focuses on reviewing the impact of DNA methylation on AD pathology and discusses the po-tential role of methylation in regulating the onset and progression of AD.Finally,by examining characteristics of DNA methylation in blood samples from AD patients,aiming to provide new insights and strategies for ear-ly screening of AD.
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