Sepsis patients have low survival rates,high mortality rates,and poor prognosis,making ear-ly identification of pathogens particularly crucial.Metagenomic next-generation sequencing(mNGS)enables unbiased detection of all microorganisms in clinical samples,providing greater sensitivity,accuracy,and effi-ciency in early detection of sepsis pathogenic microorganism compared to traditional culture techniques.With the continuous development of next-generation sequencing technology,the clinical application value of mNGS in sepsis diagnosis will further improve.This article reviews the advantages,clinical applications,progress,challenges,and prospects of mNGS in the early diagnosis of sepsis.
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