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晚期非小细胞肺癌免疫治疗再挑战的研究进展

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肺癌可分为非小细胞肺癌(NSCLC)和小细胞肺癌两大病理组织学类型,其中NSCLC最为常见,多数患者在确诊时即为晚期。近年来,免疫检查点抑制剂(ICIs)的应用改善了晚期肿瘤的治疗结果,尤其显著延长了晚期NSCLC患者的生存期。由于种种原因中断ICI治疗后的治疗策略对患者意义重大,免疫再挑战作为备选方案之一,目前已有相关研究数据。该文就免疫治疗再挑战在晚期NSCLC中的研究进展做一综述,回顾相关最新研究,为临床治疗提供参考,并探索与更好结果相关的因素。
Research progress in re-challenge of immunotherapy for advanced non-small cell lung cancer
Lung cancer can be classified into two major histopathological types:non-small cell lung cancer(NSCLC)and small cell lung cancer,with NSCLC being the most common type.Most patients are di-agnosed at an advanced stage.In recent years,the application of immune checkpoint inhibitors(ICIs)has im-proved the treatment outcomes of advanced tumors,particularly significantly prolonging the survival of pa-tients with advanced NSCLC.Due to various reasons,treatment strategies after ICI discontinuation are of great significance to patients.Re-challenge of immunotherapy,as one of the alternative options,has generated rele-vant research data.This article reviews the research progress of immunotherapy re-challenge in advanced NSCLC,summarizes the latest relevant studies,provides references for clinical treatment,and explores factors associated with better outcomes.

Advanced stageNon-small cell lung cancerImmune checkpoint inhibitorsRe-chal-lengeRe-treatmentReview

李小青、梁静、朱宇熹

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重庆医科大学附属第一医院肿瘤科,重庆 400016

重庆医科大学附属金山医院肿瘤科,重庆 400016

晚期 非小细胞肺癌 免疫检查点抑制剂 再挑战 再治疗 综述

重庆医科大学未来医学青年创新团队支持计划项目

W0188

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(18)