A preliminary study of pre-treatment lipid levels in patients with nasopharyngeal carcinoma
Objective To investigate changes in pre-treatment lipid levels in patients with nasopharyn-geal carcinoma and to explore whether they can be used as predictors of nasopharyngeal carcinoma.Methods A total of 131 nasopharyngeal cancer patients with pathologically confirmed diagnosis and complete data from 2013-2022 in the People's Hospital of Guangxi Zhuang Autonomous Region were selected as the nasopharyngeal cancer group,and the control group consisted of 119 randomly selected health checkups,and the lipid parameters of nasopharyngeal cancer patients prior to treatment were detected,including total choles-terol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein choles-terol(HDL-C),apolipoprotein A1(Apo A1),apolipoprotein B(ApoB)and lipoprotein a[Lp(a)]values were measured and statistically analyzed.Results All lipid parameters in the nasopharyngeal cancer group were statistically significant when compared to the control group(P＜0.000 1).Comparison between M staging groups,in which the differences in TC,LDL-C,and ApoB were statistically significant(P＜0.01).The results of the subjects'operating characteristic(ROC)curves showed that the area under the curve(AUC)of TC,HDL-C,ApoA1,Lp(a),TC/HDL-C,LDL-C/HDL-C and ApoA1/ApoB were＞0.7.Among them,the AUC of TC/HDL-C,LDL-C/HDL-C,and ApoA1/ApoB were the highest,at 0.82,0.77,0.75,with sensitivity of 0.70,0.70,0.65,specificity of 0.88,0.82,0.78,and cut-off values of＞3.97,＞2.50,＜1.24,respectively.Conclusion Abnormalities in TC,TG,LDL-C,HDL-C,ApoA1,ApoB,and Lp(a)levels are found in nasopha-ryngeal cancer patients before treatment.TC,LDL-C and ApoB are found to be significantly higher in the group with distant metastases compare with the group without distant metastases in M staging.TC/HDL-C,LDL-C/HDL-C and ApoA1/ApoB lipid ratio parameters can be used as predictors of nasopharyngeal carcino-ma development with good sensitivity and specificity.
万方数据
维普
