Expression and correlation of serum vitamin D and homocysteine in PCOS patients
Objective To investigate the value of serum vitamin D and homocysteine(Hcy)in the diag-nosis of polycystic ovary syndrome(PCOS)and their correlation.Methods A total of 54 PCOS patients aged 18-40 years old who were treated or hospitalized in the Reproductive Center of the hospital from January to December 2022 were selected as the PCOS group,and 50 healthy women aged 18-40 years old were included as the control group.The serum vitamin D and Hcy levels of all subjects were detected,and the differences be-tween the PCOS group and the control group were compared.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of vitamin D and Hcy alone or in combination for PCOS.Pearson correlation analysis was used to explore the correlation between serum vitamin D and Hcy in people with vitamin D levels below the cut-off value(47.16 nmol/L)in the control group and the PCOS group(low vitamin D group).Results The body weight[(66.98±11.27)kg],body mass index(BMI)[(26.98±3.79)kg/m2]and serum Hcy level[(11.10±2.59)μmol/L]in the PCOS group were significantly higher than those in the control group[(61.26±6.66)kg,(24.04±4.28)kg/m2,(9.16±1.75)µmol/L],while the serum vita-min D level[(44.45±13.49)nmol/L]was significantly lower than that in the control group[(71.57±15.71)nmol/L],the difference was statistically significant(P＜0.05).ROC curve analysis showed that the sensitivi-ty of body weight was 44.4％and the specificity was 88.0％.The sensitivity of BMI was 59.3％,and the sen-sitivity was 78.0％.The sensitivity and specificity of vitamin D were 75.9％and 94.0％,respectively.The sensitivity and specificity of Hcy were 68.9％and 60.0％,respectively.The sensitivity of the combined diag-nosis of the four indicators was 88.9％,and the specificity was 92.0％.In addition,serum vitamin D was neg-atively correlated with Hcy in the control group,PCOS group and low vitamin D group(r=-0.429 1,-0.751 6,-0.918 2,P＜0.05).Conclusion The sensitivity and specificity of the combination of the four in-dexes in the diagnosis of PCOS are better than those of the single index.There was a negative correlation be-tween serum vitamin D and Hcy in PCOS patients.Therefore,combined detection of multiple indicators can be considered clinically for the diagnosis of PCOS.
万方数据
维普
