Rationality evaluation of proton pump inhibitors in preventing of NSAIDs related gastric mucosal injury in orthopedics
Objective To investigate the use of proton pump inhibitors(PPIs)for preventing non-ster-oidal anti-inflammatory drug(NSAID)related gastric mucosal injury in orthopedic patients and to evaluate its rationality,providing a reference for the proper use of PPIs.Methods A retrospective survey was conducted,collecting data from January 1,2022,to December 31,2022,on orthopedic patients who used PPIs to prevent NSAID-related gastric mucosal injury.The study assessed whether patients had indications for prophylactic use of PPIs and then evaluated the appropriateness of drug selection,timing of administration,dosage,and du-ration of treatment in cases with indications.Results Out of 307 patients,62(20.20％)did not have indica-tions for prophylactic use of PPIs.Among the 245 instances where there were indications,83 instances(33.88％)involved inappropriate medication use,primarily due to unsuitable drug selection,inappropriate timing of administration,inappropriate frequency of administration,and excessively long treatment duration.Conclusion The inappropriate use of PPIs to prevent NSAID-related gastric mucosal injury in the orthopedics department is notable.Physicians should strictly control the indications for medication use,and pharmacists should enhance prescription review to jointly promote the rational use of drugs.
OrthopedicsProton pump inhibitorsNonsteroidal anti-inflammatory drug-related gastric mucosal injuryPreventionRational drug use
万方数据
维普
