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二甲基亚砜的医学应用及研究进展

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二甲基亚砜是一种具有多种生物学功能的极性有机溶剂,目前在医学领域被作为冷冻保护剂广泛应用于冰冻保存器官及细胞等,其本身具有消炎、镇痛、利尿和镇静等药理作用,且作为医药用品相对安全有效,因此也作为医药溶剂及药物的载体大量用于医药行业和临床给药。近年来,二甲基亚砜的核辐射防护效果研究也受到了广泛关注,此类研究为机体多组织器官放射损伤共性发病机制与防护研究提供了新的思路。然而,其生理学和药理学特性并未被完全阐明,该文就目前国内外关于二甲基亚砜的医学应用及安全性研究予以综述,以期为进一步研究及应用提供参考。
Medical application and research progress of dimethyl sulfoxide
Dimethyl sulfoxide(DMSO)is a polar organic solvent with various biological functions.Cur-rently,it is widely used as a cryoprotectant in the medical field to cryopreserve organs and cells.It has phar-macological effects such as anti-inflammation,analgesia,diuresis and sedation,and is relatively safe and effec-tive as a medical product.Therefore it is widely used in the pharmaceutical industry and clinical administration as a pharmaceutical solvent and drug carrier.In recent years,research on the nuclear radiation protection effect of DMSO has also received much attention,this type of research provides new insights into the common path-ogenesis and protection of radiation damage to multiple organs and tissues in the body.However,its physio-logical and pharmacological properties have not been fully elucidated.This article reviewed the current medical applications and safety of DMSO at home and abroad,with a view to provide references for further research and application.

Dimethyl sulfoxideOrganic solventMedical applicationToxic effectReview

袁婵、张一波、蒋卓言、郭若冰

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宁夏职业技术学院宁夏开放大学,宁夏银川 750001

云南医药健康职业学院口腔医学院,云南昆明 650032

宁夏医科大学总医院药剂科,宁夏银川 750001

二甲基亚砜 有机溶剂 药理作用 毒性作用 综述

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(19)