Research progress in the construction and application of animal models of brain metastases
Brain metastases are one of the common complications of advanced malignant tumors.The study of their occurrence,development and therapeutic mechanisms is essential to improve patient survival.The development of animal models provides an important tool for in-depth exploration of brain metastasis mechanisms and facilitates the development and evaluation of novel therapeutic strategies.This article reviews the latest research progress in the construction and application of animal models of brain metastasis,covering different types of models,including homozygous transplantation models,xenograft models,and genetically en-gineered mouse models.These models play an important role in simulating the process of brain metastasis,an-alyzing the regulatory mechanism of brain metastasis and evaluating the efficacy of drugs.In addition,the pa-per discusses the advantages and disadvantages of the existing models,and looks forward to the potential ap-plication of animal models of brain metastasis in the future to enhance clinical relevance and promote individu-alized treatment.
万方数据
维普
