Analysis of high-risk factors for brain metastasis in non-small cell lung cancer
Objective To analyze the high-risk factors of brain metastasis in non-small cell lung cancer(NSCLC).Methods A retrospective analysis was conducted on 258 NSCLC patients admitted to Clinical On-cology School of Fujian Medical University/Fujian Cancer Hospital/Fudan University Affiliated Cancer Hos-pital Fujian Hospital,including their gender,age,clinical and pathological types,molecular pathological infor-mation,and combined with the treatment methods used,to comprehensively analyze the high-risk factors of brain metastasis of NSCLC.Results(1)The incidence of brain metastasis increased in the young and female patients,as well as the non-small cell patients with EGFR mutations and ALK gene rearrangements.(2)The young NSCLC patients had a higher risk of meningeal metastasis,while the EGFR mutated NSCLC patients had a significantly increased risk of meningeal metastasis.(3)For the NSCLC patients with brain metastases,targeted therapy was combined with brain radiation therapy,anti-tumor angiogenesis,and immunotherapy;if the patient developed meningeal metastasis,anti-tumor angiogenesis therapy should be performed on the basis of targeted therapy.Conclusion High-risk factors for brain metastasis in NSCLC include youth,femininity,EGFR mutations,and concomitant ALK rearrangement mutations.Early identification and intervention of these high-risk factors can help improve the survival rate and quality of life of NSCLC patients with brain me-tastases.
万方数据
维普
