Effect of Dingxin decoction combined with paroxetine on serum neurotransmitters in patients with generalized anxiety of liver depression transforming into fire type
Objective To observe the efficacy of Dingxin decoction combined with paroxetine in the treatment of generalized anxiety disorder(GAD)of liver depression transforming into fire type and its effect on serum neurotransmitter levels.Methods From June 2021 to June 2023,a total of 80 patients with GAD of liver depression transforming into fire type diagnosed and treated in our hospital were selected and randomly divided into two groups,namely the observation group(Dingxin decoction combined with paroxetine hydro-chloride treatment,n=40)and the control group(paroxetine hydrochloride treatment,n=40).The efficacy of the two groups was observed,and the scores of Hamilton Anxiety Scale(HAMA)and TCM symptoms in the two groups were recorded.The levels of serum norepinephrine(NE),5-hydroxytryptamine(5-HT),glutamic acid(Glu),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were detected,and the incidence of adverse reactions in the two groups was compared.Results In terms of efficacy,the observation group had a greater advantage,and the total effective rate was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the HAMA score and TCM symptom score of the two groups were significantly lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of NE and Glu in the two groups were lower than those before treatment,and the level of 5-HT was increased.The levels of NE and Glu in the observation group were lower than those in the control group,and the level of 5-HT was higher than that in the control group(P＜0.05).After treat-ment,the levels of CRP,TNF-α and IL-6 in the two groups were significantly decreased,and those in the ob-servation group were lower than the control group,differences being significant(P＜0.05).The total incidence of adverse reactions in the observation group and the control group was 17.50％and 25.00％,respectively.There was no significant difference in the total incidence of adverse reactions between the two groups(X2=0.672,P=0.412).Conclusion Dingxin decoction combined with paroxetine can effectively alleviate the so-matic and mental anxiety symptoms of GAD patients with liver depression transforming into fire type,regu-late the level of neurotransmitters,reduce the level of inflammation,and have no serious adverse reactions and high safety.
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