Effect of dexamethasone preloading on pulmonary oxygenation function in pediatric cardiac surgery
Objective To observe the effect of dexamethasone in cardiopulmonary bypass priming(CPB)solution on pulmonary oxygenation function in pediatric cardiac surgery,and provide corresponding ba-sis for clinical practice.Methods From February 2023 to January 2024,54 children with congenital heart dis-ease(CHD)underwent elective ventricular septal defect repair and/or atrial septal defect repair surgery were selected from the Heart Center of Guiyang Maternal and Child Health Hospital.All patients were randomly divided into two groups,with 27 cases in each group.The control group did not use dexamethasone,and 5 mg/kg dexamethasone was added to the priming solution in the dexamethasone group.Blood samples were taken before CPB(T0),CPB for 15 minutes(T1),aortic opening for 5 minutes(T2),at the end of CPB(T3)and CPB ending for 2 hours(T4)after anesthesia induction,and arterial blood gas was analyzed,and respiratory index(RI)and oxygenation index(OI)were calculated.Results The RI index of the control group was 2.52±2.57 at T2,which was significantly higher than that of dexamethasone group(1.39±1.42),and the difference was statistically significant(P＜0.05);There was no significant difference in OI index and a/A between the two groups of patients(P＞0.05).There was no significant difference in postoperative tracheal extubation rate and the duration of mechanical ventilation in ICU(P＞0.05).Conclusion Dexamethasone can improve the pulmo-nary oxygenation function after CPB to a certain extent for a certain period of time.
万方数据
维普
