Study on the diagnosis value of blood culture positive alarm time combined with PCT and CRP in bacterial bloodstream infection
Objective To study the diagnosis value of blood culture positive alarm time(TTP)com-bined with procalcitonin(PCT)and C-reactive protein(CRP)in bacterial bloodstream infection(BSI).Methods A total of 700 patients with bacterial BSI admitted to the hospital from January 2022 to June 2023 were selected for the experiment and as the infection group.Another 100 cases identified as blood culture con-tamination during the same period were selected as the control group.Detecting and comparing the levels of TTP,PCT,and CRP in two groups,and comparing the efficacy of different detection methods in diagnosing bacterial BSI.In addition,comparing the levels of TTP,PCT,and CRP in patients with different types of pathogen infections and varying degrees of infection.Results The TTP of the infected group was(12.66±3.43)h,which was shorter than that of the control group[(20.11±5.19)h],while the serum PCT and CRP levels were(1.79±0.42)ng/mL and(41.73±7.55)mg/L,respectvely,both higher than those of the control group[(0.03±0.01)ng/mL and(3.55±1.01)mg/L],with statistically significant differences(P＜0.05).U-sing blood culture results as the"gold standard",the sensitivity,specificity,and accuracy of TTP combined with PCT and CRP in diagnosing bacterial BSI were 91.00％,97.00％,and 91.75％,respectively,which were higher than those of the above three indicators separately,and the differences were statistically significant(P＜0.05).The PCT level of Gram-positive bacteria infected patients was lower than that of Gram-negative bac-teria infected patients(P＜0.05),and the differences were statistically significant(P＜0.05).There was no statistically significant difference in TTP and CRP levels among patients infected with different types of pathogens(P＞0.05).The levels of PCT and CRP in patients with severe infection were higher than those in patients with mild to moderate infection,the differences were statistically significant(P＜0.05).Conclusion TTP combined with PCT and CRP has better efficacy in the diagnosis of bacterial BSI,and can effectively i-dentify the types of pathogens,and provide a reliable basis for evaluating the severity of infection in patients.
万方数据
维普
