Effect of Mudan granule adjuvant therapy on nerve conduction velocity and TCSS score in patients with diabetic peripheral neuropathy
Objective To observe the effect of Mudan granule on nerve conduction velocity and Toronto Clinical Neuropathy Score(TCSS score)in patients with diabetic peripheral neuropathy(DPN).Methods A total of 86 patients with DPN admitted to this hospital from May 2022 to June 2023 were selected as the re-search object,and they were randomly divided into control group and observation group,with 43 cases in each group.Both groups received routine hypoglycemic therapy,while the control group was treated with lipoic acid.On this basis,the observation group was treated with Mudan granule,both for 4 weeks.Sensory nerve conduction velocity,TCSS score and adverse reactions were compared between the two groups.Results After treatment,the conduction velocity of median nerve,superficial peroneal nerve and deep peroneal nerve in the two groups increased,and the improvement in the observation group was more significant,with statistical sig-nificance(P＜0.05).After treatment,the scores of neurological symptoms,sensation and reflex in both groups decreased,especially in the observation group,with statistical significance(P＜0.05).After treatment,the whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity and fibrinogen in the two groups decreased,especially in the observation group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(X2=0.104,P=0.747).Conclusion Adjuvant therapy with Mudan granule can improve the blood circulation of DPN pa-tients,promote the improvement of peripheral nerve symptoms,and increase the nerve conduction velocity.Adjuvant therapy is safe and can be widely used in clinic.
万方数据
维普
