The dynamic regulation of epigenetic modifications plays an important role in the occurrence and development of tumors.Enhancer of zeste homolog 2(EZH2)is abnormally expressed or mutated in mul-tiple types of tumors,which is involved in epigenetic modification of histones and plays a carcinogenic role.At present,the carcinogenic effect of EZH2 and the anticancer mechanism of EZH2 inhibition have not been fully understood.Immune cells interact with tumor cells through tumor microenvironment,and EZH2 is also crucial for the regulation of immune cells.This review elucidate the role of EZH2 in immune cells,especially in cancer patients,and provides new ideas for the immunotherapy of EZH2.
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