Research progress of podocyte disease based on mitochondrial dysfunction
Mitochondria,as a semi-autonomous organelle,play a complex role in maintaining cell func-tion.Podocyte injury is the central link in the pathogenesis of podocyte disease.In recent years,with the deep-ening of research,the status of mitochondrial dysfunction in podocyte injury has been paid more and more at-tention.At present,a large number of experimental models can verify that mitochondrial damage and dysfunc-tion are related to the imbalance of podocyte homeostasis.Specifically,abnormalities in various mitochondrial biological processes can lead to podocyte damage,such as mitochondrial respiratory chain dysfunction,mito-chondrial dynamics abnormalities,mitochondrial biogenesis and autophagy abnormalities.This study will re-view the role of mitochondria in podocytes and the effect of its dysfunction on podocyte injury,in order to pro-vide new ideas for targeted therapy of podocyte diseases.
万方数据
维普
