Relationship between serum LDL and ApoA-1 levels and progression free survival in patients with extensive small cell lung cancer
Objective To investigate the relationship between serum low density lipoprotein(LDL),apolipoprotein A-1(ApoA-1)and progression free survival in patients with extensive small cell lung cancer.Methods The clinical data of 145 patients with extensive-stage small cell lung cancer(observation group)ad-mitted to our hospital from March 2020 to March 2023 were collected.Patients in the observation group com-pleted six cycles of chemotherapy and were followed up for one year.Additionally,the physical examination data of 145 healthy individuals who underwent physical examinations at the same hospital during the same pe-riod and matched the observation group in terms of gender,age,and body mass index were collected(control group).The serum levels of LDL and ApoA-1 were compared between the two groups.The serum levels of LDL and ApoA-1 at different time points during treatment in the observation group were also compared.The progression free survival and prognosis of patients in the observation group during the follow-up period were collected.Spearman correlation analysis was used to assess the correlation between serum LDL,ApoA-1 lev-els,and progression free survival in patients with extensive-stage small cell lung cancer.Cox regression analy-sis was conducted to identify the factors influencing poor prognosis in patients with extensive-stage small cell lung cancer.Results The serum LDL level in observation group was higher than that in control group,and the serum ApoA-1 level was lower than that in control group,with statistical significant differences(P＜0.05).The serum LDL levels at 6 treatment cycles were higher than those at admission and 3 treatment cy-cles,and the serum ApoA-1 levels were lower than those at admission and 3 treatment cycles,with statistical significant differences(P＜0.05).The progression free survival of 145 patients with extensive stage small cell lung cancer was 4-16 months,the median survival time was 7.1 months,103 cases had poor prognosis and 42 cases had good prognosis.Through Spearman correlation analysis,the results showed that serum LDL levels were negatively correlated with the progression free survival of extensive small cell lung cancer(r=-0.617,P＜0.001),and serum ApoA-1 levels were positively correlated with the progression free survival of extensive small cell lung cancer(r=0.509,P＜0.001).The levels of serum neuron specific enolase,carcinoembryonic antigen,cytokeratin 19 fragment antigen,and LDL in the poor prognosis group were higher than those in the good prognosis group,while the level of ApoA-1 level was lower than those in the good prognosis group,with statistical significant differences(P＜0.05).According to Cox regression analysis,serum neuron specific eno-lase,carcinoembryonic antigen,cytokeratin 19 fragment antigen,serum LDL at admission and serum ApoA-1 level at admission were all factors affecting poor prognosis of extensive stage small cell lung cancer(P＜0.05).Conclusion Serum LDL levels are negatively correlated with the progression free survival of patients with extensive small cell lung cancer,and serum ApoA-1 levels are positively correlated with the progression free survival of patients with extensive small cell lung cancer.Serum LDL and ApoA-1 levels are factors af-fecting poor prognosis of patients with extensive stage small cell lung cancer.
Extensive small cell lung cancerProgressive free survivalLow-density lipoproteinApolipoprotein A-1Correlation
万方数据
维普
