Exploration of the relationship between serum chemokine levels and poor short-term prognosis in patients with advanced NSCLC
Objective To explore the relationship between serum levels of chemokines and poor short-term prognosis in patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 257 pa-tients with advanced NSCLC admitted to our hospital from August 2019 to September 2023 were selected as the study subjects.The serum levels of CX3 chemokine ligand 1(CX3CL1),CC chemokine ligand 5(CCL5),and CCL20 were measured.The differences in serum levels of CX3CL1,CCL5,and CCL20 among patients with different pathological characteristics were compared.During the course of treatment,5 patients were trans-ferred to other hospitals,leaving a final inclusion of 252 patients.Based on their recent prognosis,the patients were divided into a poor prognosis group(n=65)and a good prognosis group(n=187).The general informa-tion and serum levels of CX3CL1,CCL5,and CCL20 were compared between the two groups.Logistic regres-sion models were used to analyze the risk factors for poor recent prognosis in these patients.Receiver operat-ing characteristic(ROC)curves were plotted to assess the predictive value of individual and combined detec-tion of serum CX3CL1,CCL5,and CCL20 for poor recent prognosis in patients with advanced NSCLC.Results The serum levels of CX3CL1,CCL5 and CCL20 in patients with adenocarcinoma and TNM stage Ⅳwere higher than those in patients with squamous cell carcinoma and TNM stage Ⅱ b-Ⅲ,and the differences were statistically significant(P＜0.05).The incidence of poor short-term prognosis in 252 patients was 25.79％(65/252).The serum levels of CX3CL1,CCL5,CCL20 and the proportion of TNM stage Ⅳ in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P＜0.05).Elevated serum levels of CX3CL1,CCL5,CCL20 and TNM stage Ⅳ were all risk fac-tors for poor short-term prognosis in patients with advanced NSCLC(P＜0.05).The sensitivity and area un-der ROC curve of the combination of serum CX3CL1,CCL5 and CCL20 in predicting poor prognosis in mid to late stage NSCLC patients were 93.85％and 0.916 respectively,which were higher than those predicted by each indicator alone,and the differences were statistically significant(P＜0.05),and the specificity was basi-cally consistent with that predicted by each indicator alone.Conclusion The levels of serum CX3CL1,CCL5 and CCL20 are closely related to the pathological type and TNM staging of patients with advanced NSCLC,and they are all risk factors for poor short-term prognosis,which have predictive value for short-term progno-sis,and the combination of the three can further improve the predictive value.
万方数据
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