Effects of amiodarone combined with metoprolol on electrocardiogram indexes and serum levels of GDF-15 and Gal-3 in patients with acute myocardial infarction complicated with arrhythmia
Objective To investigate the effects of amiodarone(AD)combined with metoprolol(MP)on electrocardiogram indexes and serum growth differentiation factor-15(GDF-15)and galectin-3(Gal-3)lev-els in patients with acute myocardial infarction complicated with arrhythmia.Methods A total of 126 patients with acute myocardial infarction complicated with arrhythmia admitted to Puyang People's Hospital and Chi-nese Medicine Hospital of Puyang from July 2020 to August 2023 were selected and divided into AD group(AD treatment)and MP combined group(AD combined with MP treatment)by simple random grouping method,with 63 cases in each group.Patients in both groups were treated for two months.The clinical effica-cy,cardiac function[including left ventricular end-diastolic diameter(LVDD),left ventricular systolic dys-function(LVSD)and left ventricular ejection fraction(LVEF)],electrocardiogram indexes,serum levels of GDF-15,Gal-3,inflammatory factors and incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the MP combined group was significant-ly higher than that of the AD group[96.83％(61/63)vs.87.30％(55/63)],and the difference was statistical-ly significant(P＜0.05).After two months of treatment,the levels of LVDD,LVSD,serum CDF-15,Gal-3 and inflammatory factors in the two groups were significantly lower than those before treatment,and the LVEF and electrocardiogram indexes were significantly higher than those before treatment.After two months of treatment,the levels of LVDD,LVSD,serum CDF-15,Gal-3 and inflammatory factors in the MP combined group were significantly lower than those in the AD group,and the LVEF and electrocardiogram indexes were significantly higher than those in the AD group,the differences were statistically significant(P＜0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of AD and MP2 has a good clinical effect,which can sig-nificantly improve the electrocardiogram index and cardiac function level of patients,and reduce the levels of serum GDF-15,Gal-3 and inflammatory factors.
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