The clinical data and treatment of a case of multiple myeloma(MM)with central nervous system(CNS)infiltration(CNS-MM)admitted to the Department of Hematology of the hospital were retro-spectively analyzed.A 61-year-old male patient with the a late stage and accompanied by high-risk genetics at the time of diagnosis had the high-risk characteristics of CNS-MM.After previous multi-line treatment with CD38 monoclonal antibody and pomalidomide,the patient had multiple recurrences involving the CNS.After admission,selinexor,bendamustine and dexamethasone were selected for systemic chemotherapy.At the same time,methotrexate,cytarabine and dexamethasone were injected intrathecally to maintain the progression-free survival of the disease for nearly 12 months,and the overall survival has reached 58 months.The selinexor-based can effectively treat CNS-MM,and the successful diagnosis and treatment provide a certain reference for clinical practice.
关键词
中枢神经系统/多发性骨髓瘤/浸润/病例报告
Key words
Central nervous system/Multiple myeloma/Infiltration/Case reports
维普
万方数据