现代医药卫生2024,Vol.40Issue(23) :4092-4096.DOI:10.3969/j.issn.1009-5519.2024.23.026

miRNA在妊娠相关疾病中的研究进展

Research progress of miRNA in pregnancy-related diseases

王霞利 何西彦 曲涛 杨青 孙晓彤
现代医药卫生2024,Vol.40Issue(23) :4092-4096.DOI:10.3969/j.issn.1009-5519.2024.23.026

miRNA在妊娠相关疾病中的研究进展

Research progress of miRNA in pregnancy-related diseases

王霞利 1何西彦 2曲涛 2杨青 1孙晓彤2
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作者信息

  • 1. 甘肃中医药大学,甘肃 兰州 730000;甘肃省人民医院,甘肃 兰州 730000
  • 2. 甘肃省人民医院,甘肃 兰州 730000
  • 折叠

摘要

最近有研究表明,微小RNA(miRNA)在妊娠相关疾病中发挥一定的诊治作用.miRNA是一种小的非编码RNA,可通过结合靶mRNA的3'非翻译区诱导翻译抑制或降解,可能是监测各种疾病的理想生物标志物.因此,探索miRNA对于明确妊娠相关疾病的发病机制及靶向治疗具有重要意义.该文综述了miRNA在妊娠相关疾病中的研究进展,及早发现妊娠相关疾病及其隐匿病情,达到早诊断、早干预的目的,最终改善母儿结局.

Abstract

Recent studies have shown that microRNA(miRNA)play a role in the diagnosis and treat-ment of pregnancy-related diseases.MiRNA is small non-coding RNA that can induce translation inhibition or degradation by binding to the 3'untranslated region of target mRNA and may be ideal biomarkers for monito-ring various diseases.Therefore,the exploration of these miRNA is of great significance for clarifying the pathogenesis and targeted therapy of pregnancy-related diseases.This article reviews the research progress of miRNA in pregnancy-related diseases,so as to detect pregnancy-related diseases and their hidden diseases early,achieve the purpose of early diagnosis and intervention,and ultimately improve maternal and infant out-comes.

关键词

微小RNA/妊娠相关疾病/诊断/治疗/综述

Key words

MicroRNA/Pregnancy-related diseases/Diagnosis/Therapy/Review

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出版年

2024
现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
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