Male fertility preservation has developed rapidly in recent years and has become a research hotspot due to the high incidence of infertility worldwide,the continuous decline in semen quality,the increas-ing incidence of cancer and the increasing demand for non-cancer population.The purpose of male fertility preservation is to prevent future fertility risks,which can be applied not only to tumor patients,but also to non-tumor populations affected by other diseases,occupational exposure,late marriage and late childbearing.Sperm preservation,testicular tissue and spermatogonial stem cell cryopreservation are the methods of fertility preservation.However,at present,the preservation of male fertility faces many challenges,such as non-stand-ard quality control management,lack of public awareness and ethical issues and so on.Therefore,this paper reviews the current situation,methods and adaptive population of male fertility preservation,and thinks about related problems and looks forward to the future development direction,in order to provide theoretical basis and new ideas for clinical physicians to further explore.