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脓毒症诊断及预后相关生物标志物的研究进展

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脓毒症是感染引起的炎症反应失调进而导致的危及生命的器官功能障碍,是重症医学科常见疾病,具有极高的病死率。其发病率在全球范围内不断增加,每年超过200万例。脓毒症的早期诊断对于及时开始适当的治疗以改善患者的预后及降低医疗成本至关重要。在急诊科,脓毒症的早期识别是具有挑战性的,原因有几个,包括由于人满为患和不同临床条件下症状重叠导致的就诊时间有限。故迫切需要具有良好预测能力、方便的生物标志物来帮助医生识别高危患者并做出治疗决策。该文对临床上易于获取的脓毒症诊断及预后相关生物标志物进行综述。
Research progress of biomarkers related to prognosis and diagnosis of sepsis
Sepsis is a life-threatening organ dysfunction caused by inflammation disorder caused by in-fection.It is a common disease in intensive care medicine with a high mortality rate.Its incidence is increasing globally,with more than two million cases per year.Early diagnosis of sepsis is essential for timely initiation of appropriate treatment to improve patient outcomes and reduce healthcare costs.Early identification of sepsis in the emergency department is challenging for several reasons,including limited visit times due to overcrow-ding and overlapping symptoms in different clinical conditions.Therefore,there is an urgent need for conven-ient biomarkers with good predictive power to help physicians identify high-risk patients and make treatment decisions.This article reviews the biomarkers related to prognosis and diagnosis of sepsis that are readily a-vailable in clinical practice.

SepsisDiagnosisSerological markersPrognosisReview

谷柳莹、姜雯娟

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新疆医科大学研究生学院,新疆乌鲁木齐 830017

新疆维吾尔自治区人民医院急救中心,新疆 乌鲁木齐 844000

脓毒症 诊断 血清学标志物 预后价值 综述

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(23)