Application of integrated anticoagulation pharmaceutical outpatient clinic in the management of warfarin anticoagulation therapy for patients with atrial fibrillation within a medical consortium
Objective To explore the effectiveness and safety of an integrated anticoagulation pharma-ceutical outpatient clinic within a medical consortium in improving warfarin anticoagulation therapy for pa-tients with atrial fibrillation(AF).Methods A total of 127 patients with valvular/non-valvular AF who re-ceived warfarin anticoagulation therapy and were followed up at the First People's Hospital of Fuyang District and its affiliated community health centers from August 2020 to February 2022 were selected and divided into a control group(n=64)and an observation group(n=63)based on a random number table.Patients in the control group were managed using the regular outpatient clinic model,while those in the observation group were managed using the integrated anticoagulation pharmaceutical outpatient clinic model within the medical consortium.The international normalized ratio(INR)target attainment rate(INR target range:2.0-3.0),medication rationality,incidence of adverse events,medication adherence,and medication safety cognition abili-ty were assessed within 6 months.Results The INR target attainment rate in the observation group was 71.43％ (45/63),significantly higher than that in the control group[29.69％ (19/64)],with a statistically significant difference(P＜0.01).In terms of medication rationality,the observation group had significantly lower incidence rates of inappropriate dosage and usage[19.05％ (12/63)],adverse drug interactions[11.11％ (7/63)],clinical diagnosis inconsistent with indications[6.35％ (4/63)],and adverse events[11.11％ (7/63)]compared to the control group[46.88％ (30/64),37.50％ (24/64),31.25％ (20/64),48.44％ (31/64),respectively],with statistically significant differences(P＜0.01).The medication adherence score[(6.87±1.78)points]and medication safety cognition ability score[(8.14±1.79)points]in the ob-servation group were higher than those in the control group[(5.61±1.63)points,(5.86±1.27)points,re-spectively],with statistically significant differences(P＜0.05).Conclusion The management model of the integrated anticoagulation pharmaceutical outpatient clinic within a medical consortium can improve the effec-tiveness and safety of anticoagulation therapy for patients with AF.
Medical consortiumAnticoagulation therapy managementOutpatient clinic modelAtrial fibrillationWarfarin
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