Study on the effect of esmolol on inflammatory mediators and cardiac function in patients with septic cardiomyopathy
Objective To investigate the effect of esmolol on inflammatory mediators and cardiac func-tion in patients with septic cardiomyopathy(SCM).Methods A retrospective analysis was conducted on the clinical data of 61 patients diagnosed with SCM in the emergency intensive care unit and general ICU of Fuzhou First General Hospital from May 2019 to April 2022.The patients were divided into an observation group(30 patients receiving esmolol in addition to general conventional treatment)and a control group(31 patients receiving general conventional treatment only).General baseline data and previous medical histories of the two groups were collected,including heart rate,mean arterial blood pressure,body temperature,and re-spiratory rate at admission.Sequential Organ Failure Assessment(qSOFA)and Acute Physiology and Chron-ic Health Evaluation Ⅱ(APACHE Ⅱ)scores were assessed on the day of admission.Blood inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)]and cardiac function indicators[left ventricular ejection fraction(LVEF),cardiac index(CI)]were measured on the day of admission and on day 7.Results Seven days af-ter treatment,the levels of CRP and PCT in the observation group were lower than those in the control group[(36.5±15.2)mg/L vs.(56.2±13.5)mg/L,(9.2±1.4)ng/I)vs.(17.3±2.6)ng/L,respectively],while LVEF and CI were higher[(0.51±0.06)％ vs.(0.46±0.04)％,(3.35±0.15)L/(min·m2)vs.(3.05±0.19)L/(min·m2),respectively],with statistically significant differences(P＜0.05).Conclusion The com-bination of esmolol with conventional treatment in SCM patients can reduce the levels of inflammatory media-tors and improve cardiac function.
EsmololSeptic cardiomyopathyInflammatory mediatorsCardiac function
万方数据
维普
