Association between TNFSF15 gene polymorphism and ulcerative colitis:a meta-analysis
Objective To systematically evaluate the association between the C/T polymorphism at the rs3810936 locus of the tumor necrosis factor superfamily member 15(TNFSF15)gene and ulcerative colitis(UC).Methods Databases including EMbase,PubMed,Ovid,Springer,CNKI,Wanfang Data,VIP Informa-tion(Chinese Journal Service Platform),and others were searched for case-control studies on the association between the C/T polymorphism at the rs3810936 locus of the TNFSF15 gene and UC,from inception to Feb-ruary 2024.Two researchers independently screened the literature,extracted data,and assessed the risk of bias in the included studies.Meta-analysis was conducted using Review Manager 5.3 and Stata 12.0 software.Re-sults A total of 9 case-control studies were included,involving 2 173 UC patients(case group)and 2 744 healthy individuals(control group).The C/T polymorphism at the rs3810936 locus of the TNFSF15 gene was associated with the risk of UC.Individuals carrying the CC+CT and CC genotypes had a higher risk of UC than those with the TT genotype.Those carrying the CT+TT genotype had a lower risk of UC than those with the CC genotype.Individuals carrying the C allele had a higher risk of UC than those with the T allele,with statistically significant differences(odds ratios=1.25,1.41,0.82,1.17;95％ confidence intervals 1.06-1.46,1.17-1.71,0.71-0.93,1.08-1.27;P=0.006,＜0.001,0.003,＜0.001).Conclusion The C/T polymorphism at the rs3810936 locus of the TNFSF15 gene is associated with the development of UC,and car-rying the C allele increases the risk of UC.However,due to the limitations of the number and quality of the included studies,this conclusion still needs to be verified by large-sample,high-quality studies.
Tumor necrosis factor superfamily member 15Ulcerative colitisGene polymor-phismMeta-analysis
万方数据
维普
