Incidence and influencing factors of financial toxicity in cancer patients:a meta-analysis
Objective To systematically evaluate the incidence and influencing factors of financial toxic-ity in cancer patients.Methods Databases including China Biology Medicine(CBM),China National Knowl-edge Infrastructure(CNKI),VIP Information(Chinese Journal Service Platform),Wanfang Data,PubMed,EMbase,Web of Science,and the Cochrane Library were searched for cohort studies and cross-sectional studies on financial toxicity and its influencing factors in cancer patients,from inception to October 2023.Two re-searchers independently screened the literature,extracted data,and assessed the quality of the included stud-ies.Meta-analysis of the incidence and influencing factors of financial toxicity in cancer patients was conducted using Stata 15.1 software.Results A total of 24 studies involving 21 188 patients were included,with 7 462 patients experiencing financial toxicity and 11 influencing factors identified.The meta-analysis results showed that the incidence of financial toxicity in cancer patients was 41％[95％ confidence interval(95％ CI):33％,49％].The influencing factors for financial toxicity in cancer patients included non-white race[odds ratio(OR)=2.39,95％ CI(2.14,2.68),P＜0.001],younger age[OR=1.04,95％ CI(1.02,1.06),P＜0.001],uninsured status[OR=1.79,95％ CI(1.48,2.18),P＜0.001],low income[OR=3.2,95％ CI(2.8,3.66),P＜0.001],no spouse[OR=1.97,95％ CI(1.76,2.22),P＜0.001],higher education level[OR=0.56,95％ CI(0.46,0.67),P＜0.001],shorter duration since diagnosis[OR=1.60,95％ CI(1.28,2.00),P＜0.001],unemployment[OR=2.64,95％ CI(1.88,3.71),P＜0.001],later cancer stage[OR=2.19,95％ CI(1.70,2.84),P＜0.001],no additional commercial health insurance[OR=4.93,95％ CI(2.23,10.93),P＜0.001],and receipt of radiotherapy/chemotherapy[OR=2.72,95％ CI(1.72,4.31),P＜0.001].Conclusion The in-cidence of financial toxicity is high in cancer patients,and is influenced by factors such as non-white race,younger age,uninsured status,no spouse,higher education level,low income,unemployment,shorter duration since diagnosis,later cancer stage,no additional commercial health insurance,and receipt of radiotherapy/chemotherapy.
万方数据
维普
