Analysis of Blood Drug Concentration and Efficacy of Valproate Acid in the Treatment of Adult Bipolar Disorder
Objectives To evaluate the correlation between blood concentration,clinical efficacy,and adverse reac-tions of valproate in the treatment of adult bipolar disorder.Methods A retrospective study was conducted to ana-lyze the clinical data of 60 adult bipolar disorder patients admitted to our hospital from January 2021 to April 2023.The effects of age,gender,weight,combined medication,and dosage on valproate blood concentration were observed,and the relationship between valproate blood concentration and clinical efficacy as well as adverse reac-tions was explored.Results The age,weight,and gender of patients have no significant impact on the blood con-centration of valproic acid.When the dosage is 0.75～1 g/d,the average blood drug concentration is(95.97±24.26)μg/mL,which achieves the optimal dosage effect.The number of combined medications increases,and the blood concentra-tion of valproic acid decreases.The incidence of adverse reactions of valproate is 38.75%,and the plasma concen-tration is positively correlated with the incidence of adverse reactions.When the blood concentration of valproic acid exceeds 120 μg/mL,adverse reactions significantly increase.Spearman correlation analysis shows that there is a pos-itive correlation between concentration and efficacy.The optimal therapeutic effect can be achieved when the con-centration of sodium valproate is between 50 and 120 μg/mL.Conclusions The blood concentration of valproate is safe and effective between 50 and 120 micrograms per milliliter.Regular monitoring of blood drug concentration can serve as a reference for timely and reasonable adjustment of drug dosage in adult patients with bipolar disorder who use valproate,providing a basis for the implementation of individualized drug administration plans.
ValproateBlood drug concentrationCurative effectBipolar disorderAdverse reactions
万方数据
维普
