Study on the Expression of TGF-β1/Smad2 and Smad7 Signaling Pathways in Atrial Remodeling in Patients with Atrial Fibrillation
Objectives To explore TGF-β1 The relationship between the expression and distribution changes of Smad2 and Smad7 in the TGF-β1 signaling pathway and the occurrence and development of atrial fibrillation fibrosis.Methods A total of 52 patients who underwent cardiac surgery in our hospital from January 2018 to December 2020 were selected and divided into two groups based on the nature of the lesion,and there are 24 patients in the atrial fibrillation group(RAF)and 28 patients in the sinus rhythm group(RSR).By detecting the expression of Smad2,Smad7,and fibronectin in the right atrial tissue of patients with atrial fibrillation and sinus rhythm undergoing cardiac surgery,the expression levels,spatial distribution,and changes in fibronectin expression levels of Smad2 and Smad7 were compared.Results The expression of Smad2 in the right atrium of patients with atrial fibrillation was significantly higher than that of patients with sinus rhythm,while the expression of Smad7 was significantly lower than that of patients with sinus rhythm,and the expression level of fibronectin in the fibrosis factor group was significantly higher than that in the sinus rhythm group(P<0.05).Conclusions TGF-β1/Smad2 and Smad7 signaling pathways are involved in structural remodeling caused by atrial fibrosis in atrial fibrillation.
万方数据
维普
