The Correlation Between TyG index,RC and NonHDL-C and the Severity of Vascular Lesions in Patients with Acute Coronary Syndrome
Objectives To investigate the correlation between non-high-density lipoprotein cholesterol(NonHDL-C),triglyceride glucose index(TyG index)and remnant cholesterol(RC)and the severity of coronary vascular disease in patients with acute coronary syndrome(ACS).Methods A total of 147 patients treated by PCI in our hospital were selected as the research objects.Baseline data were collected and the severity of coronary artery disease was assessed using the Gensini score.According to Gensini score,the patients were divided into mild group(4≤Gensini score≤16,n=52)and moderate to severe group(Gensini score>16,n=95).Multivariate Logistic regression analysis was used to determine the independent risk factors for the severity of arterial vascular disease in ACS patients.Spearman correlation analysis was used to evaluate the correlation between RC,NonHDL-C and TyG index and Gensini score,and ROC curve was used to evaluate the predictive value of RC,TyG index and NonHDL-C for the severity of arterial vascular disease in ACS patients.Results Compared with the mild group,the levels of NonHDL-C,RC and TyG indexes were significantly increased in moderate and severe group(P<0.05).Multivariate Logistic regression analysis showed that RC(OR=7.673,P=0.012),TyG index(OR=2.537,P=0.013)and NonHDL-C(OR=2.144,P=0.001)were independent risk factors for the severity of coronary artery disease in ACS patients.The AUC of RC,TyG index and NonHDL-C were 0.653,0.671 and 0.711,respectively.The combined AUC of TyG index and NonHDL-C was 0.739.Spearman correlation analysis showed that Gensini score was positively correlated with TyG index,RC and NonHDL-C levels(P<0.05).Conclusions The increase of RC,TyG index and NonHDL-C may be the risk factors for the severity of coronary artery disease in ACS patients,and have certain predictive value for the severity of vascular lesions in the future.
万方数据
维普
