Research Progress on the Relationship Between Serum Progesterone,Estradiol,Human Chorionic Gonadotropin Levels in Early Pregnancy and Embryo Development Arrest
In recent years,with the increasing incidence of embryo damage,how to predict and give early interven-tion to reduce the risk of embryo damage has become a major problem that needs to be solved urgently in clinic.There are many complicated causes of embryo damage,among which endocrine factors are important contents of clinical research.At present,the main indicators for predicting pregnancy outcomes in early pregnancy involve pro-gesterone(P),estradiol(E2)and human chorionic gonadotropin(HCG),etc.It is found that there are abnormal ex-pressions of these indexes in patients with a history of embryo damage.Through consulting related literatures,it is found that there are certain regularities in the above-mentioned index levels in different gestational ages,that is,P and E2 are usually in the optimal critical state at 4 weeks of pregnancy,and HCG rises the fastest before 6 weeks of pregnancy.After 7 weeks of pregnancy,P and E2 are in the luteal-placental transition period,and rise to the highest level at 8 to 10 weeks of pregnancy.This stage is also the key stage to determine whether pregnancy can proceed smoothly.Therefore,the detection of P,E2 and HCG in different pregnancy ages to understand their corre-lation with pregnancy outcome can effectively reflect the status of embryonic development status and provide some reference for early treatment and intervention.
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