The Diagnostic Value of Combined Detection of PIVKA-Ⅱ,AFU,and NLR in the Diagnosis of Alpha-fetoprotein-negative Hepatocellular Carcinoma
Objectives To investigate the value of combined detection of new tumor markers abnormal prothrombin(PIVKA-Ⅱ),α-L-fucosidase(AFU)and peripheral blood neutrophil/lymphocyte ratio(NLR)in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma(AFP-NHCC).Methods A total of 200 patients with liver disease treated in our hospital from January 2021 to December 2023 were selected as the study objects,including 100 patients with AFP-NHCC as the observation group and 100 patients with benign liver lesions as the control group.By detecting PIVKA-Ⅱ,AFU and NLR of all subjects,the differences between the two groups were compared,and the area under the ROC curve was calculated to judge the diagnostic efficacy of each index.Results The levels of PIVKA-Ⅱ,AFU and NLR in the observation group increased significantly compared with those in the control group(P<0.05).Among the three indicators,PIVKA-Ⅱ had the best efficacy in the diagnosis of AFP-NHCC,with AUC of 0.790,sensitivity of 57.0％and specificity of 100％.The AUC of the combined detection of the three indicatorsof AFP-NHCC was 0.868,the sensitivity was 66.0％,and the specificity was 96.0％.Conclusions PIVKA-Ⅱ,AFU and NLR have certain diagnostic value for AFP-NHCC patients,and the combined detection of the three can significantly improve the diagnostic efficiency and reduce missed diagnosis.
Hepatocellular carcinomaAbnormal prothrombinBiomarkerDiagnostic value
万方数据
维普
