Objectives To investigate the diagnostic value of combined detection of serum calcitonin(CT),vascular endothelial growth factor(VEGF)and tumor abnormal protein(TAP)in the diagnosis of thyroid cancer.Methods The clinical data of 64 patients with thyroid cancer admitted to my Hospital from March 2022 to December 2023 were retrospectively selected as the observation group,and 66 patients with benign thyroid nodule during the same period were selected as the control group.The basic data of all subjects were analyzed and organized,and serum CT,VEGF and TAP tests were performed.Serum CT,VEGF and TAP levels were compared between the two groups.The influencing factors of thyroid carcinoma were analyzed.The diagnostic value of serum CT,VEGF and TAP alone and combined in detecting thyroid cancer were analyzed.Results The serum levels of CT,VEGF and TAP in the observation group were significantly higher than those in control group(P＜0.05).Serum CT(OR=1.950,95%CI 1.765～2.155),VEGF(OR=2.059,95%CI 1.791～2.366)and TAP(OR=2.206,95%CI 1.930～2.520)were independent risk factors for thyroid cancer(P＜0.05).The value of area under the curve(AUC)of combined detection of serum CT,VEGF and TAPwas significantly higher than that of single detection(Z=3.027,3.525,2.846,P＜0.05).Conclusions The combined detection of serum CT,VEGF and TAP is of high value in the diagnosis of thyroid cancer,which can be used as the main reference for the auxiliary diagnosis of the disease.
关键词
甲状腺癌/降钙素/血管内皮生长因子/异常糖链糖蛋白/诊断价值
Key words
Thyroid cancer/Calcitonin/Vascular endothelial growth factor/Tumor abnormal protein/Diagnostic value
维普
万方数据