ADRB1 Arg389gly Gene Polymorphism in Patients with Cardiovas-cular Disease in Nanchang Area
Objectives To investigate the distribution and regional and ethnic differences of ADRB1 Arg389Gly gene in patients with cardiovascular diseases in Nanchang area.Methods A total of 590 patients with cardiovascular diseases who were hospitalized in the First Affiliated Hospital of Nanchang University from July 2020 to January 2022 were selected as the research objects.TaqMan technique was applied to genotyping and identification of ADRB1 Arg389Gly.The expression of ADRB1 Arg389Gly gene in differentgenders,ages and diseases was analyzed,and the gene expression in Nanchang was compared with that reportedin different regions.Results The results of ADRB1 Arg389Gly genotyping were in line with Hardy-Weinberg equilibrium.The frequency of ADRB1 Arg389Gly genotype in patients with cardiovascular diseases in the Nanchang area was significantly higher in patients with GG genotype≥65 years old than in patients with GG genotype<65 years old(P<0.05).The GC genotype frequency in the AS group was significantly lower than that in the NAS group(P<0.05).There was no significant difference in other genotypes and allele frequencies(P>0.05).There were significant differences in genotype and allele frequency between Nanchang and Arabia and other seven region(P<0.05),while there was no significant difference in genotype and allele frequency between Nanchang and Huai'an,Shanghai,and South India(P>0.05).Conclusions TheADRB1 Arg389Gly gene in Nanchang area was in accordance with Hardy-Weinberg equilibrium.The expression of ADRB1 Arg389Gly gene was not consistent in different populations inNanchang area,and there exist regional and ethnic differences.
万方数据
维普
