首页|不同新型降糖药在2型糖尿病患者中的心血管改善作用进展

不同新型降糖药在2型糖尿病患者中的心血管改善作用进展

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2 型糖尿病是导致心血管疾病死亡的重要原因之一,合理控制血糖,可降低心血管疾病的发生风险,改善心血管疾病患者的预后结局.传统降糖药仅能降低血糖,对大血管合并症影响较小,而新型降糖药在 2 型糖尿病患者降糖预后方面有着诸多优势,也取得了较好的临床效果.新型降糖药包括肠促胰素类药物、二肽基肽酶-4 抑制剂、钠-葡萄糖协同转运蛋白 2 抑制剂、葡萄糖激酶激动剂、胰岛淀粉样物多肽类似物等.本文总结 2 型糖尿病合并心血管疾病的发病现状,探讨不同新型降糖药对 2 型糖尿病患者心血管保护作用,展望不同新型降糖药物未来应用方向.
Progression of Cardiovascular Improvement of Different Novel An-tidiabetic Drugs in Patients with Type 2 Diabetes
Type 2 diabetes is an important cause of death from cardiovascular disease.Reasonable glucose control can reduce the risk of cardiovascular disease and improve the prognostic outcomes of cardiovascular disease pa-tients.Traditional hypoglycemic drugs only reduce blood glucose and have less impact on macrovascular complica-tions,while new hypoglycemic drugs have many advantages in the hypoglycemic prognosis of type 2 diabetes pa-tients and have also achieved good clinical results.These drugs include incretin drugs,dipeptidyl peptidase-4 in-hibitors,sodium-glucose cotransporter 2 inhibitors,glucokinase agonists,islet amyloid peptide analogs,etc.This pa-per summarizes the current situation of type 2 diabetes with cardiovascular disease,discusses the cardiovascular protection of different new hypoglycemic drugs in type 2 diabetes patients,and looks forward to the future applica-tiondirection of different new hypoglycemic drugs.

Cardiovascular protective effectsCardiovascular diseaseNew hypoglycemic drugsIncretin-based drugsDipeptidylpeptidase-4 inhibitor

王茹、姚朱华

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天津市人民医院,天津 300121

心血管保护作用 心血管疾病 新型降糖药物 肠促胰素类药物 二肽基肽酶-4抑制剂

2024

现代诊断与治疗
南昌市医学会 南昌市医学科学研究所

现代诊断与治疗

影响因子:0.736
ISSN:1001-8174
年,卷(期):2024.35(11)