The Relationship Between BDNF and EGF Levels and Clinical Symptoms andCognitive Function in Patients with Schizophrenia Before and After Treatment
Objectives Toinvestigate the relationship between the levels of Brain-derived Neurotrophic Factor(BDNF)and Epidermal Growth Factor(EGF)and cognitive function in schizophrenic patients before and after treatment.Methods A total of 51 patients with schizophrenia admitted to our hospital from January 2021 to January 2022 were selected.The relationship between serum BDNF and EGF levels and clinical symptoms and cognitive function before and after treatment was analyzed.Results After treatment,the BDNF level was significantly higher than that before treatment,while EGF levels,Positive and Negative SymptomScores(PANSS)were significantly lower than those before treatment(P＜0.05).The duration of stroopcolor word test A to D cards after treatment was significantly shorter than that before treatment(P＜0.05).After treatment,the scores of each dimension in the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)increased significantly compared to those before treatment(P＜0.05).Spearman correlation analysis showed that after treatment,BDNF level was negatively correlated with PANSS dimension scores and A-D card duration,and positively correlated with RBANS dimension scores(P＜0.05).After treatment,EGF level was positively correlated with PANSS scores and A-D card duration,and negatively correlated with RBANS scores(P＜0.05).Conclusions The level of BDNF in patients with schizophrenia increased after treatment,which is negatively correlated with clinical symptoms and positively correlated with cognitive function.The decrease in EGF levels was positively correlated with clinical symptoms and negatively correlated with cognitive function.
Brain-derived neurotrophic factorSchizophreniaCognitive function
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