Analysis of the Effect of Mitral Regurgitation on the Outcome of TAVI for Severe Aortic Stenosis
Objectives To investigate the influence of the degree of mitral regurgitation on the effect of Transcatheter Aortic Valve Implantation(TAVI)in the treatment of severe aortic stenosis.Methods A total of 107 patients with severe aortic stenosis admitted to our hospital from January 2021 to March 2023 were selected as the study objects,and all the patients underwent TAVI treatment.According to the degree of mitral regurgitation,the patients were divided into non-severe group(68 cases)and severe group(39 cases).The baseline data,postoperative and pre-and post-operative differences of various indicators[left ventricular ejection fraction(LVEF),left atrial diameter(LAD),mitral regurgitation area(MRA)]were compared between the two groups.According to whether major adverse cardiovascular and cerebrovascular events(MACE)occurred within one year of postoperative follow-up,the patients were divided into good group(58 cases)and poor group(49 cases).The postoperative LVEF,LAD,MRA,and NT-proBNP of the two groups were statistically analyzed.Binary logistic regression was used to analyze the relationship between postoperative LVEF,LAD,MRA,NT-proBN and prognosis of patients.Results The LVEF before and after surgery in the severe group was significantly lower than that in the non-severe group(P<0.05).The preoperative LAD and MRA in the severe group were significantly higher than those in the non-severe group(P<0.05).The differences of LVEF,LAD,and MRA before and after surgery in the severe group were significantly higher than those in the non-severe group(P<0.05).The preoperative LVFE in the poor group was significantly lower than that in the good group(P<0.05),while there was no significant difference in LAD and MRA between the two groups before operation(P<0.05).Compared with the preoperative levels,LVEF in the poor group did not increase significantly after operation(P>0.05),while LVEF in the good group increased significantly after operation(P<0.05).LAD and MRA levels of the two groups decreased significantly after operation(P<0.05).The postoperative LVEF of the poor group was significantly lower than that of the good group(P<0.05),while LAD and MRA in the poor group were significantly higher than those of the good group(P<0.05).Postoperative LVEF,LAD,and MRA are all associated with poor prognosis in patients(P<0.05).Conclusions Patients with severe aortic stenosis and varying degrees of mitral regurgitation can be treated with TAVI.Clinical indicators such as LVEF,LAD,MRA,NT-proBNP can reflect the degree of mitral regurgitation and the benefit of treatment.
Severe aortic stenosisMitral regurgitationMajor adverse cardiovascular and cerebrovascular events
万方数据
维普
