Therapeutic efficacy of ginkgo biloba extract combined with sandwiched moxibustion on coronary heart disease with syndrome of heart blood stasis
Objective It is to observe the clinical efficacy and safety of ginkgo biloba extract injection combined with sandwiched moxibustion in the treatment of coronary heart disease with syndrome of heart blood stasis.Methods Seventy patients with coronary heart disease with syndrome of heart blood stasis treated in Shanghai Minhang District Hospital of In-tegrated Traditional Chinese and Western Medicine from January 2022 to April 2023 were randomly divided into treatment group and control group,with 35 cases in each group.Both groups were given basic therapy,and the control group was giv-en ginkgo biloba extract injection by intravenous drip,and the treatment group was given ginkgo biloba extract injection by intravenous drip combined with sandwiched moxibustion with Panax ginseng powder and peach kernel powder on Tanzhong acupuncture.Both groups were treated for 14 days.The changes of TCM syndrome scores and serum levels of N-terminal B-type natriuretic peptide precursor(NT-proBNP),ultrasensitive troponin T(cTnT),fibrinogen(FIB),D-dimer(D-D),C-reactive protein(CRP),serum creatinine(SCr),blood urea nitrogen(BUN),blood uric acid(UA)before and after the treatment in the two groups were observed,the percentage of major symptoms and ECG efficacy,TCM syndrome effica-cy,and the occurrence of adverse reactions in the two groups were calculated or assessed after treatment.Results The TCM symptom scores and serum levels of NT-proBNP,cTnI,FIB,D-D,CRP,SCr,BUN,and UA of patients in the two groups were significantly lower than those before treatment(all P＜0.05),and the TCM symptom scores and serum levels of NT-proBNP,cTnI,D-D,CRP in the treatment group were significantly lower than those in the control group(all P＜0.05).The proportion of chest tightness,chest pain,shortness of breath,body and limb coldness,rib fullness pain,cough and phlegm,and heaviness of limbs in the treatment group were significantly lower than those in the control group(all P＜0.05).There was no statistically significant difference in the total effective rate of electrocardiogram between the two groups(P＞0.05),and the total effective rate of TCM symptoms in the treatment group was significantly higher than that in the control group[94.12%(32/34)vs.77.14%(27/35),P＜0.05].No allergic event to Ginkgo biloba extract injection occurred in the two groups,and no adverse reactions such as impaired liver and kidney function,gastrointestinal bleeding,acute cardiovascular and cerebral vascular events,and coagulation disorders occurred in either group.Conclusion Ginkgo biloba extract injection combined with sandwiched moxibustion at Tanzhong acupoint can significantly improve patients'symptoms of Yang deficiency,phlegm,blood stasis and blood hypercoagulability,reduce inflammatory reactions,and pro-tect the myocardium in the treatment of coronary heart disease with syndrome of heart blood stasis.
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