Effect of compound probiotics in patients after unilateral total knee arthroplasty
Objective It is to investigate the effect of compound probiotics in patients after unilateral total knee arthro-plasty.Methods Ninety-two patients who underwent unilateral total knee arthroplasty in the Third Hospital of Hebei Medi-cal University from January to December 2021 were selected and divided into 2 groups using a randomized,double-blind,placebo-controlled method,with 2 cases lost from the control group and 1 case lost from the experimental group during fol-lowing-up,and finally 44 cases in the control group and 45 cases in the experimental group completed the study.Starting from the 1st postoperative day,the patients in the control group were given maltodextrin and those in the experimental group were given compound probiotics,both twice per day,3 g per time,continuously treated for 14 days.The gastrointestinal symptom rating scale(GSRS)scores,pain VAS scores,WOMAC scores,SF-36 scores,and blood-related indicators of the patients in the two groups were observed at different postoperative time points.Results The differences in GSRS score,VAS scores WOMAC scores at different times were statistically significant in each group(all P＜0.05),and the GSRS scores at postoperative day 3,the VAS scores at postoperative day 14 in the experimental group were significantly lower than those in the control group(P＜0.05),but there were no significant differences in the WOMAC scores at different postoperative time points between the two groups(all P＞0.05).The differences in the total scores and physiological function scores,vi-tality scores,social function scores,and mental health scores of SF-36 at different postoperative time points were statistical-ly significant between the two groups(all P＜0.05),and the differences in the physical function scores,somatic pain scores,general health scores,and emotional function scores at different postoperative time points were not statistically sig-nificant between the two groups(all P＞0.05);the total scores,vitality scores,and mental health scores of SF-36 of pa-tients in the experimental group were significantly higher than those in the control group at postoperative day 14(all P＜0.05).The differences in leukocyte counts,monocyte percentages,neutrophil/lymphocyte ratios,and the level of C-reac-tive protein at different postoperative time points were statistically significant in each group(all P＜0.05),and the differ-ences in leukocyte counts,monocyte percentages,neutrophil/lymphocyte ratios,and the level of C-reactive protein at the postoperative day 14 were not statistically significant between the two groups(all P＞0.05).Conclusion Compound probi-otics can improve the gastrointestinal symptoms,pain,quality of life and psychological health of patients after unilateral to-tal knee arthroplasty.
probioticsunilateral total knee arthroplastyGSRS scoreVAS scoreSF-36 score
万方数据
维普
