Effects of Trifoliate Orange granules for dispersing stuffiness on malnutrition and protein-bound toxins in peritoneal dialysis patients with syndrome of spleen deficiency and Qi stagnation
Objective It is to observe the effects of Trifoliate Orange granules for dispersing stuffiness on malnutrition and protein-bound toxins in peritoneal dialysis patients with syndrome of spleen deficiency and Qi stagnation.Methods Six-ty maintenance peritoneal dialysis patients with malnutrition who were followed up in the Department of NephrologyⅡ and outpatient clinic of the Affiliated Hospital of Shaanxi University of Chinese Medicine from October 2021 to October 2022 were selected,and they were divided into control group and treatment group according to the principle of randomization and control,with 30 cases in each group.The control group was treated with basic western medicine,and the treatment group was treated with Trifoliate Orange granules for dispersing stuffiness based on the treatment of the control group,both groups were treated for 3 months.The changes in the renal function indexes and dialysis adequacy indexes[blood creatinine(SCr),urea nitrogen(BUN),and urea clearance index(Kt)],and nutritional status indexes[hemoglobin(Hb),serum albumin(ALB),serum prealbumin(PA),body mass index(BMI),and body mass index(BMI),triceps skinfold(TSF),arm circumference(AC),arm muscle circumference(AMC)],protein-bound toxin indicators[levels of indole sulphate(IS),p-cresol sulphate(pCS)in serum and peritoneal dialysis fluid],scores of Chinese medicine syndrome and Modified Quantitative Subjective Global Assessment(MQSGA)were observed after 3 months of treatment.Results After 3 months of treatment,the levels of SCr,BUN,pCS in serum,the levels of IS in serum and peritoneal dialysis fluid,and scores of TCM syndrome and MQSGA in the treatment group were significantly lower than those before treatment(all P<0.05),Kt and the levels of Hb,ALB,PA were significantly higher than those before treatment(all P<0.05),and the changes of the rest of the indexes were not obvious(all P>0.05),only the level of SCr was significantly reduced in the control group(P<0.05);after treatment,the levels of ALB and PA in the treatment group were significantly higher and the levels of serum pCS and scores of TCM syndrome were significantly lower than those in the control group(all P<0.05).Conclusion Trifoliate Orange granules for dispersing stuffiness can improve the nutritional status,reduce the level of IS in serum and peritoneal dialysis fluid and the level of pCS in serum of peritoneal dialysis patients with syndrome of spleen deficiency and Qi stagnation,and can protect their kidneys and peritoneum.
Trifoliate Orange granules for dispersing stuffinessperitoneal dialysismalnutritionprotein-binding toxin
万方数据
维普
