Correlation between Chinese medical syndrome type and degree of dyspnea and lung function in patients with interstitial lung disease
Objective It is to investigate the characteristics of traditional Chinese medicine(TCM)syndromes and their relationship with degree of dyspnea and lung function in patients with interstitial lung disease(ILD).Methods A cross-sectional study was used to collect data from patients diagnosed with ILD who visited the outpatient clinic and ward of the Department of TCM Lung Diseases Division I and the ward of the Department of Respiratory and Critical Care Medicine Division III of China-Japan Friendship Hospital from January 2022 to March 2023,and to collect the patients'general infor-mation,four diagnosis information of TCM,mMRC classification,and the data from the recent pulmonary function tests(FVC%pred,FEV1%pred,FEV1/FVC,and DLCO SB%pred),the final diagnosis of the western medicine,and the re-strictive ventilation function,obstructive ventilation function,diffusion function classification were calculated,the distribu-tion characteristics of TCM syndrome in ILD patients with different western medicine diagnostic types were analyzed,and the mMRC classification,lung function and pulmonary function classification in patients with different TCM syndromes were compared.Results Two hundreds and three patients with ILD were collected,their finally western medical diagnosis were as follows:66 cases(32.5%)with connective tissue disease-related ILD,22 cases(10.8%)with idiopathic pulmonary fibrosis,43 cases(21.2%)with other known causes and idiopathic ILD,and 72 cases(35.5%)with non-classified ILD,and the differences in the gender distribution among the patients with different western medical diagnosis were significant(all P<0.05).The proportion of lung Qi deficiency was the highest in the main TCM syndromes,followed by Yin defi-ciency with lung dryness,lung-kidney Qi deficiency,and lung-kidneyQi-Yin deficiency;the proportion of blood stasis was the highest in the accompanied syndromes,followed by phlegm-dampness and phlegm-heat.The differences in the distribu-tion of TCM main syndromes and phlegm-dampness syndrome among patients with different western medical diagnostic types were not significant(all P>0.05),while the differences in phlegm-heat syndrome and blood stasis syndromes were signifi-cant(all P<0.05).The differences in the distribution of mMRC classification among patients with different main TCM syndromes and between patients with or without blood stasis were statistically significant(all P<0.05),the differences were also significant among patients with lung Qi deficiency and lung-kidney Qi deficiency,lung-kidney Qi-Yin deficiency,and between Yin deficiency and lung dryness and lung-kidney Qi deficiency(all P<0.05).The differences in FVC%pred,FEV1%pred,and DLCO SB%pred among patients with different TCM main syndromes and between patients with or without blood stasis were statistically significant(all P<0.05);the differences in FVC%pred among patients with lung Qi deficiency syndrome and Yin deficiency with lung dryness in TCM main syndromes were statistically significant when com-pared with patients with lung-kidney Qi deficiency syndrome and lung-kidney Qi-Yin deficiency syndrome(all P<0.05);the differences in FEV1%pred among patients with lung Qi deficiency syndrome,lung-kidney Qi deficiency syndrome and lung-kidney Qi-Yin syndrome were significant(all P<0.05),and the difference in FEV1%pred was also significant be-tween Yin deficiency with lung dryness syndrome and lung-kidney Qi deficiency syndrome(P<0.05);the differences in DLCO SB%pred of patients with lung Qi deficiency syndrome were significant when compared with those with Yin deficien-cy with lung dryness syndrome,lung-kidney Qi deficiency syndrome and lung-kidney Qi Yin deficiency syndrome(all P<0.05).Conclusion At the beginning of ILD,lung Qi deficiency is the main syndrome,lung Qi deficiency syndrome and Yin deficiency with lung dryness syndrome were mild ILD,and lung-kidney Qi deficiency syndrome,lung-kidney Qi-Yin deficiency were severe ILD.With the progression of the disease,the patients'mMRC classification increases and their lung function decreases;most patients with ILD accompanied with blood stasis syndrome,and their mMRC classification is high-er while their lung function is worse compared with those without blood stasis.The TCM syndrome,mMRC classification and lung function have good homogeneity in evaluating the degree of dyspnea of patients,and can refer to and reflect each other.
万方数据
维普
