Efficacy of Ginseng Astragalus Rehmannia decoction plus decoction of four ingredients including Peach Kernel and Safflower on stage Ⅲ～Ⅳ diabetic kidney disease and its effect on oxidative stress
Objective It is to observe the clinical efficacy of Ginseng Astragalus Rehmannia decoction plus decoction of four ingredients including Peach Kernel and Safflower on stageⅢ,Ⅳdiabetic kidney disease(DKD)and its effect on oxi-dative stress.Methods A total of 126 DKD patients treated at the Outpatient Clinic and Inpatient Department of Nephrology of the Third Hospital of Hebei Medical University from March 2021 to March 2023 were selected and randomly divided into control group and observation group,with 63 patients in each group.Both groups were treated with conventional western medicine,additionally,the observation group was treated with modified Ginseng Astragalus Rehmannia decoction plus de-coction of four ingredients including Peach Kernel and Safflower,and both groups were treated for 12 weeks.The changes of Chinese medicine syndrome scores and renal function indexes[24 h urine protein quantification and blood urea nitrogen(BUN),serum creatinine(SCr)],fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triacylglycerol(TG),blood rheology indexes(fibrinogen,plasma viscosity,whole blood viscosity),oxidative stress indexes[(plasma malondialdehyde(MDA),superoxide dismutase(SOD)]before and after treatment in the two groups were observed,and the clinical efficacy,occurrences of endpoint events and adverse reactions of the two groups were calculated.Results Fifty-nine cases in the control group and 58 cases in the observation group completed the study.The syndrome scores and levels of 24 h urine protein quantification,BUN,SCr,FPG,HbA1c,TC,TG,fibrinogen,plasma viscosity,whole blood viscosity and MDA were significantly decreased,while the levels of SOD were significantly increased after treatment in the two groups(all P＜0.05),the syndrome scores and levels of 24 h urine protein quantification,BUN,fibrinogen,plasma viscosity,whole blood viscosity and MDA were significantly lower,while the level of SOD was signifi-cantly higher after treatment in the observation group than those in the control group(all P＜0.05).After treatment,the total effective rate of the observation group was significantly higher than that of the control group[84.48%(49/58)VS.66.10%(39/59),P＜0.05].The differences in the incidence of endpoint events and adverse reactions were not statisti-cally significant between the two groups(all P＞0.05).Conclusion Ginseng Astragalus Rehmannia decoction plus decoc-tion of four ingredients including Peach Kernel and Safflower can effectively alleviate clinical symptoms,reduce urinary pro-tein excretion,protect renal function,improve glucose and lipid metabolism disorders,regulate hypercoagulable state,and resist oxidative stress in patients with stage Ⅲ～Ⅳ DKD,its efficacy is better than conventional western medicine.
Ginseng Astragalus Rehmannia decoctiondecoction of four ingredients including Peach Kernel and Saf-flowerdiabetic kidney diseaseproteinuriaoxidative stress
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