Effect of electroacupuncture cycle therapy on endometrial tolerance and in vitro fertilization-embryo transfer in infertile patients with decreased ovarian reserve
Objective It is to investigate the effects of electroacupuncture cycle therapy on endometrial tolerance and outcomes of in vitro fertilization-embryo transfer(IVF-ET)in infertile patients with decreased ovarian reserve(DOR).Methods Seventy-eight infertile patients with DOR who were to undergo IVF-ET in Liuzhou Maternal and Child Health Hos-pital from April 2021 to April 2022 were randomly divided into control group and experimental group,with 39 cases in each group.Both groups underwent IVF-ET,and the experimental group was treated with electroacupuncture sequential cyclic therapy for 3 months before implantation.The endometrial thickness,endometrial volume,endometrial classification and blood flow typing,and uterine artery blood flow parameters[(bilateral uterine artery pulsatility index(PI),resistance in-dex(RI),peak systolic/diastolic(S/D)]at luteal meta phase before and after the treatment in the two groups were com-pared,and the number of eggs obtained,the number of fertilization,the number of embryos,the number of high-quality embryos,and the rates of HCG positivity,implantation,and clinical pregnancy were compared.Results Compared with those before treatment and in the control groups,the endometrial thickness and endometrial volume of patients in the experi-mental group were increased significantly after the intervention of electroacupuncture cycle,the percentage of patients with endometrial type C was decreased,the percentage of patients with endometrial type A was increased,the percentage of pa-tients with blood flow type Ⅰwas decreased,the percentage of patients with blood flow typeⅢwas increased,the uterine arterial PI,RI and S/D were decreased significantly,and the differences were statistically significant(all P＜0.05);the changes of the above indexes in the control group were not significant(all P＜0.05);The numbers of eggs,fertilization,embryos and high-quality embryos in the experimental group were significantly more than those in the control group(all P＜0.05),while the HCG-positive rate,embryo implantation rate and clinical pregnancy rate were all significantly higher than those in the control group[67.56%(25/37),58.33%(28/48),51.35%(20/37)VS.44.74%(17/38),37.03%(20/54),31.58%(20/37),all P＜0.05].Conclusion Electroacupuncture cycle treatment can significantly improve endometrial tolerance,increase embryo implantation rate and clinical pregnancy rate in infertility patients with DOR.
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维普
