Efficacy of decoction for diffusing lung,discharging turbid and calming panting on stable bronchiectasis and its effect on intestinal microecology
Objective It is to observe the effect of decoction for diffusing lung,discharging turbid and calming panting on stable bronchiectasis and its effect on intestinal microecology.Methods Ninety patients with stable bronchiectasis of syn-drome of phlegm-dampness accumulating lung treated in the First Affiliated Hospital of Guangzhou Medical University from January 2022 to January 2023 were selected as the observed subjects,and were randomly divided into western medicine group,Chinese medicine group,and combined traditional Chinese and western medicine group(combined group),with 30 cases in each group;meanwhile,30 healthy persons were randomly selected from the Physical Examination Center of the First Affiliated Hospital of Guangzhou Medical University as the blank group for the control of intestinal flora detection.The western medicine group was given ambroxol orally,the Chinese medicine group was given granules of decoction for diffusing lung,discharging turbid and calming panting orally,and the combined group was given decoction for diffusing lung,dis-charging turbid and calming panting combined with ambroxol orally.The clinical efficacy of the three groups was evaluated after 6 months of treatment,and the pulmonary function indexes[forced expiratory volume in one second(FEV1),forced volume capacity(FVC),peak expiratory flow(PEF)],bronchodilatation severity index(BSI),24-h sputum volume,a-cute exacerbation frequency,cough and sputum assessment questionnaire(CASA-Q)scores,and St.George's Respiratory Questionnaire(SGRQ)scores,and the expressions of Eubacterium rectale and Bacteroides thetaiotaomicron in fecal speci-mens(determined by PCR amplification)before and after treatment were compared among the three groups.Results At the end of treatment,the total clinical effective rate of the combined group was significantly higher than that of the traditional Chinese medicine group and western medicine group[93.3%(28/30)VS.63.3%(18/30),76.7%(23/30),all P<0.05].Compared with before treatment,FEV1,FVC and PEF were significantly increased,BSI scores and SGRQ scores,24-h sputum volume and acute exacerbation frequency were significantly reduced,the CASA-Q scores were significantly in-creased after treatment in the three groups,and the improvements of these indexes of the combined group were significantly better than those of the Chinese medicine group and western medicine group,the western medicine group was significantly better than the Chinese medicine group,the differences were all statistically significant(all P<0.05).The expressions of Eubacterium rectale and Bacteroides thetaiotaomicron in fecal specimens of the combined group and Chinese medicine group were improved significantly after treatment compared with before treatment(all P<0.05),the changes in the expressions of Eubacterium rectale and Bacteroides thetaiotaomicron were not significant in the western medicine group after treatment(all P>0.05);after treatment,the expressions of Eubacterium rectale of the combined group and traditional Chinese med-icine group were significantly lower than that of the western medicine group(both P<0.05),and the expression of Bacte-roides thetaiotaomicron were significantly higher than that of the western medicine group(both P<0.05),the differences in the expression of Eubacterium rectale and Bacteroides thetaiotaomicron were not statistically significant between the tradi-tional Chinese medicine group and combined group(both P>0.05).Conclusion Decoction for diffusing lung,discharging turbid and calming panting combined with ambroxol is more effective than they used alone in the treatment of patients with stable bronchiectasis of syndrome of phlegm-dampness accumulating lung,which can effectively alleviate the patients'condi-tions and improve their lung function and quality of life,and the mechanism may be related to regulating the microecology of intestinal flora.
bronchiectasisstable stagesyndrome of phlegm-dampness accumulating lungdecoction for diffusing lung,discharging turbid and calming pantingintestinal flora microecology
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